protein
With AI, researchers predict the location of virtually any protein within a human cell
A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer’s, cystic fibrosis, and cancer. But there are about 70,000 different proteins and protein variants in a single human cell, and since scientists can typically only test for a handful in one experiment, it is extremely costly and…
Repurposing Protein Folding Models for Generation with Latent Diffusion
PLAID is a multimodal generative model that simultaneously generates protein 1D sequence and 3D structure, by learning the latent space of protein folding models. The awarding of the 2024 Nobel Prize to AlphaFold2 marks an important moment of recognition for the of AI role in biology. What comes next after protein folding? In PLAID, we…
AI system predicts protein fragments that can bind to or inhibit a target
All biological function is dependent on how different proteins interact with each other. Protein-protein interactions facilitate everything from transcribing DNA and controlling cell division to higher-level functions in complex organisms. Much remains unclear, however, about how these functions are orchestrated on the molecular level, and how proteins interact with each other — either with other…