Multimodal Generation

Repurposing Protein Folding Models for Generation with Latent Diffusion

PLAID is a multimodal generative model that simultaneously generates protein 1D sequence and 3D structure, by learning the latent space of protein folding models. The awarding of the 2024 Nobel Prize to AlphaFold2 marks an important moment of recognition for the of AI role in biology. What comes next after protein folding? In PLAID, we…

Highlights

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This researcher turned OpenAI’s open weights model gpt-oss-20b into a non-reasoning ‘base’ model with less alignment, more freedom

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Yes, you do need a mouse with 19 buttons — here’s why

Category Collection

Repurposing Protein Folding Models for Generation with Latent Diffusion