MIT Mcgovern Institute
Rationale engineering generates a compact new tool for gene therapy
Scientists at the McGovern Institute for Brain Research at MIT and the Broad Institute of MIT and Harvard have re-engineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. The protein they created, called NovaIscB, can be adapted to make precise changes to the genetic code, modulate the…
MIT’s McGovern Institute is shaping brain science and improving human lives on a global scale
In 2000, Patrick J. McGovern ’59 and Lore Harp McGovern made an extraordinary gift to establish the McGovern Institute for Brain Research at MIT, driven by their deep curiosity about the human mind and their belief in the power of science to change lives. Their $350 million pledge began with a simple yet audacious vision:…
An ancient RNA-guided system could simplify delivery of gene editing therapies
A vast search of natural diversity has led scientists at MIT’s McGovern Institute for Brain Research and the Broad Institute of MIT and Harvard to uncover ancient systems with potential to expand the genome editing toolbox. These systems, which the researchers call TIGR (Tandem Interspaced Guide RNA) systems, use RNA to guide them to specific…