Bonnie Berger
Researchers glimpse the inner workings of protein language models
Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing new therapeutic antibodies. These models, which are based on large language models (LLMs), can make very accurate predictions of a protein’s suitability for…
A new computational model can predict antibody structures more accurately
By adapting artificial intelligence models known as large language models, researchers have made great progress in their ability to predict a protein’s structure from its sequence. However, this approach hasn’t been as successful for antibodies, in part because of the hypervariability seen in this type of protein. To overcome that limitation, MIT researchers have developed…